Well, aside from playing the living hell out of season 4 once it launches.
From what it looks like, my time-saving generalizations of the game won’t change very much with the exception of items. Trinkets being level-1 free ingame is something I’ll have to figure out in the card game.
Another thing is Heimerdinger’s and Sivir’s reworks, as both are to be in the primary set of the card game. Heimer’s have the risk of being too complex in card form, while Sivir’s is actually somewhat easier than before.